Scope
Morphological neuroscience analyzing the neocortex and selected subcortical areas with a focus on the basal ganglia and its neuronal connections. Status epilepticus is the hallmark disease of interest. Majority of the studies are exerted on the rat brain as an animal experimental model of choice. Apart from the provoked epileptic animal models, retrospective structural and functional MRI are under consideration.
The objectives and significance of the work
- To map the distribution of interneurons and to localize the inhibitory systems which can serve as neuromodulation sites in epilepsy.
- To localize and profile post-status-epilepticus neuronal degenerative changes which can serve as means of imaging diagnostics and sites of neuromodulation as well.
Program
Recommended Courses
- B90005 – Progress in neurosciences
- B90189 – Selected chapters of imaging methods in medicine (Neuroimaging)
- B90215 – Practical Medical Physics and Technology for the Leksell Gamma Knife Radiosurgery
- B90080 – Basics of statistics for biomedicine and healthcare
- Processing and analysis of microscopic images in biomedicine
State Doctoral Examination
List of questions/topics for doctoral viva voce in the field of neurosciences
Recommended References
- Jessell TM, Siegelbaum AS, Kandel ER. Principles of Neural Science. McGraw-Hill Education.
- ten Donkelaar HJ et al.. Clinical Neuroanatomy: Brain Circuitry and Its Disorders. Springer Science & Business Media.
- Mai JK, Majtanik M, Paxinos G. Atlas of the Human Brain. Academic Press.
- Osborn AG, Hedlund GL, Salzman KL. Osborn's Brain: Imaging, Pathology, and Anatomy. Elsevier.
- Paxinos G. The Human Nervous System. Academic Press.
- Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. Elsevier.
- Paxinos G. The Rat Nervous System. Academic Press.
- Borden NM, Forseen SE, Stefan C. Imaging Anatomy of the Human Brain - A Comprehensive Atlas Including Adjacent Structures. Springer Publishing Company.
- Steiner H, Tseng KY. Handbook of Basal Ganglia Structure and Function. Academic Press.
- Engel J, Pedley TA, Aicardi J. Epilepsy: A Comprehensive Textbook. Lippincott Williams & Wilkins.
- ten Donkelaar HJ, Kachlík D, Tubbs RS. An Illustrated Terminologia Neuroanatomica: A Concise Encyclopedia of Human Neuroanatomy. Springer.
Offering Positions
For topics in anatomy in kinesiology and rehabilitation, contact the supervisor.
Thesis – Calretinin immunoreactivity in the prefrontal cortical region of the rat brain.
Thesis – Distribution of calretinin-positive interneurons in the dorsal and ventral striatum of rats.
Thesis – Changes in Structure and in Inhibitory System of Hippocampus and Parahippocampal Areas in Young Animals experienced Status Epilepticus.
Requirements:
A suitable / prospective applicant must be a (or future) medical faculty graduate who intends to focus on anatomy, histology, physiology, neurology, psychiatry or neurosurgery and is interested in doctoral studies in Neurosciences. Candidates would be involved in undergraduate teaching of anatomy or histology as part of the program
Supervisors:
| prof. MUDr. Rastislav Druga, DrSc. | 257296 236 | |
