Research

The Department of Anatomy conducts medically oriented research in affiliation to the Second Faculty of Medicine, Charles University and Faculty Hospital Motol and in cooperation with local and international research institutes.  

Our ongoing scientific activity is composed of two divisions. Morphological neurosciences supervised by Professor Rastislav Druga, and in cooperation with the Czech Academy of Science. Clinical anatomy supervised by the head of the department Professor David Kachlík, and in cooperation with a wide range of local and international anatomical, histological, radiological, general and specialized surgerical, and pathological departments and institutions.

Morphological neurosciences

           MUDr. Azzat Al-Redouan 
 

The scope of the research is focused on morphological changes in diseases examining brain vital areas. The observations are carried on animal models experimentation and retrospectively on brain imaging modalities.  

  • Structure and organization of selected areas of the brain: Investigating and mapping neocortical connections via immunohistochemical staining methods on rat brain models. Designated brain areas of interest are basal ganglia, claustrum, hippocampus, thalamus, and amygdaloid body. In addition to mapping surface receptors within the investigated connections as they potentially can serve as sites for pharmacological neuromodulation.   
  • Neuronal degenerative changes in post status epilepticus: Investigating post-ictal short and long term neuronal changes in experimentally provoked seizures in animal models. The aim is to map structural and connectivity damage and observe the pattern of morphological localizations within basal ganglia, hippocampus and parahippocampal areas.
  • Neuroimaging in epilepsy: Assessing available modalities. Bridging our findings on the experimental models mapped areas of damage as a tool into clinical practice where we can develop approaches to detect those changes via imaging methods with reliable sensitivity.  
  • Vagus nerve: Meta-analysis and literature review aiming to comprehend the complexity of vagus nerve nuclei and distribution into its scattered terminal sites of innervation.

Clinical anatomy

Team: prof. MUDr. David Kachlík, Ph.D. (Supervisor & head of department)
        MUDr. Adam Whitley 
        MUDr. Jan Votava
        MUC. Michal Beneš
        MUC. Miroslav Belbl
       
 
The scope of the research is focused on morphological variations and its clinical implications. The observations are carried on dry bone specimens, cadaveric dissections, and imaging methods as well as meta-analysis of retrospective clinical data. 
 
  • Vascular variations: Tortuous arteries with special focus on ulnar and radial arteries. Aberrant arteries commonly encountered in surgical operations such as aberrant obturator artery and coeliac trunk. Venous network variations with special interest on saphenous connections, jugular veins, and suprascapular vein. Integrated project elaborating on vertebrobasilar artery course. Eyeball vasculature. 
  • Scapula morphometry: Measuring selected parameters of scapula substructures aiming to morphologically classify and detect patterns that correlate to clinical implications such as impingement syndrome, suprascapular notch stenosis, fracture sites and fixations.   
  • Peripheral nerves anatomical entrapments: Selected nerves coursing through narrow topographical spaces as they run peripherally. The aim is to define the exact and variant anatomy of potential compression sites. Nerves of interests are nerves running deep in the scapular region, branches of the radial nerve, and the sciatic nerve.
  • Variant structures and foramina of the skull: Investigating their occurrence and size. Observations are carried on mastoid foramen, vermian fossa, squamomastoid suture, suprameatal spine, postglenoid foramen, and foramen Huschkae.
  • Anatomy of the hand: Surface anatomy of the hand. Variations of deep hand muscles, especially lumbricals.
  • Sonography of musculoskeletal system: Mapping anatomical variations as tools into clinical diagnostics. Topography of interest are hand structures and scapular region with emphasis on assessment of suprascapular notch space and topography.
  • Sonography of vascular system: Mapping anatomical variations as tools into clinical diagnostics. Topography of interest are upper and lower limb veins and their variants, e.g. cubital venous perforators, intersaphenous veins and relations of the superficial veins and cutaneous nerves.

Other broader anatomical topics

An auxiliary focus to widen our comprehension of anatomy and provide communication medium.
  • Terminology and nomenclature: Revision of old and recent in practice anatomical terms. Contribution into TA. Terms proposals and definition clarifications.
  • Bioinformatics in morphology: Implementing new mathematical approaches to digital imaging morphometry.
  • Anthropology: An extension of the bone morphometry including comparative anatomy, evolution and development of bones. 
  • History of anatomy: Tracing sequence of events took part in the development of our knowledge on morphology, as well highlighting noticeable accomplishers.
  • Educational tools: Involvement in textbooks publications and editing at the level of college teaching as well as advanced references. Memorix series. 3D printing of bones. Utilizing virtual anatomy tools. Implementing ultrasound anatomy into the curriculum.

Participants in our research programmes range from expert professors, medical and science doctors, academic staff and clinicians, postgraduate and pregraduate medical students. Each with a role oriented toward matching the level of experience and intended future goals. Our projects range from large long term sequential projects to small short term projects, as well thesis projects for PhD students in one of the three programmes (Experimental surgery, Neurosciences, Imaging methods) plus narrow topics of research suitable for junior students as an extracurricular opportunity.

 

For Special Inquiries, please contact the head of the department prof. David Kachlík or the designated team member.

Created: 4. 10. 2016 / Modified: / Responsible person: MUDr. Azzat Al-Redouan.